Synthesis of 2-((4-(1H-indol-2-yl)phenyl)amino)thiazol-4(5H)-oneas a potential pharmaceutical structure

Author: Elene Katsadze
Keywords: Indole, Thyazole
Annotation:

The indole ring system is one of the most prevalent subunits in natural product chemistry and has captured the interest of organic chemists for more than a century. Particularly, 2-phenyl-substituted derivatives are of considerable interest, because of their biological and pharmacological activities. Generally, they display important psychotropic, sedative, analgesic, anti-depressive, anti-inflammatory and cytotoxic acti¬vi¬ties. Nonsteroidal compounds having estrogenic or anti-estrogenic activities are valuable for controlling estrogen-dependant cancers. Hence, it was reported that 2-phenylindole is a suitable scaffold for the development of new agents for the treatment of estrogen-responsive mammary tumors. On the other hand, Thiazole structure is found in biologically active compounds (e.g. Vitamin B) and in medications (penicillines, sulphanidamide agents). Some therapeutic preparations that contain thiazole ring, are capable slow down or completely stop multiplication of cancer cells in the diseased organs. In this regard the compounds, which contain thiazole ring condensed with benzene ring and having inhibition capacity, are notable [1-6]. Consequently, condensation of indole ring with thiazole ring makes it possible obtaining a wide range of new heterocyclic compounds revealing feasible inhibitory and intercalation activity.

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Synthesis of 2-((4-(1H-indol-2-yl)phenyl)amino)thiazol-4(5H)-oneas a potential pharmaceutical structure [en]
პოტენციური ფარმაკოლოგიური აქტიურობის მქონე 2-((4-(1H-ინდოლ-2-ილ)ფენილ)ამინო)თიაზო-4(5H)-ონი-ის სინთეზი [ka]