The effect of Creatine on IP3K/Akt/mTOR signaling pathway by the Violation of Natural Circadian Rhythm

Author: Mariam Shengelia
Keywords: Circadian rhythm, PI3K/Akt/mTor signaling pathway, creatine.
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Time organizing of physiologic processes is a fundamental feature of a biological system, which is a characteristic of all the living beings. Biological clock systems are formed by a specific genetic program and breaking this system causes changes in cellular homeostasis. Among the factors, that determine the rhythm of the ongoing processes in the body, Circadian rhythm is of paramount importance. In most cases Circadian rhythm disorder provokes changes in energy metabolism, and furthermore, triggers the development of stress processes. It is known, that endogenous creatine is actively engaged in energy processes of cell. At the same time creatine is said to be characterized by a neuromodulatory feature which in itself implies that it has an influence on the processes of nervous cells. Recent paper describes the impact of intraperitoneally injected creatine (140 mg/kg) into rats with a disturbed natural circadian rhythm for an extended period of time (30 days). Markedly, creatine-treated animals show positive changes in open-field behavioral parameters. Therefore, impact on energy mediating pathways has a positive effect on stabilization of antioxidant and effects on IP3K/Akt/mTOR-signaling cascade and protecting hippocampal cells from stress.