Model of drug delivery nanoparticle DPPC and vitamin E complex

Author: lasha dalakishvili
Co-authors: Salome Gogichaishvili
Keywords: DPPC, Vitamin E, complex model
Annotation:

Today nanoparticles and nanostructures are becoming more and more important in medicine. One of the examples are double or multilayer vesicles structure, called liposome, with phospholipids as main components. Phospholipids are fat acids with hydrophobic tails and hydrophilic heads. According to this when they are in the aqueous solution the create fluid-crystal structures and because of small distance between heads there are weak hydrogen bonds and hydrophobic bonds between tails. And this creates the 3D conformation for vesicles. This nanoparticles are considered to be harmless for human body because the phospholipids are the main molecules of the biological cells itself. Our aim was to create the physical model which could calculate the whole amount of particles in the liposome with given size. Also we created the model with is more complex and in the structure there are the molecules of the other types, for example drugs, biological molecules etc.. Main attention we gave to the hydrophobic molecules because with the nanoparticles they can circulate in the blood and whole body. We can evaluate expected location of the phospholipids and the amount of the drugs which is contained in the liposome. From the general calculations we can move to the specific materials and make our research for double layer DPPC (dipalmitoylphosphatildylcholine), with the radius of 220 nm and vitamin E (C40H80NO8P). For the first approximation we consider vesicle as a sphere and with the help of area of one phospholipid we can calculate the whole number of phospholipids in the structure. We divide the whole area of the sphere on the area of one phospholipide. Then with the help of approximation we take triangles as the best option for the location of phospholipids and structural elements. Between the phospholipids in triangle there are hydrogenic, electrostatic and hydrophobic bonds. With the help of the size of vitamin E molecule and the sizes of the triangle structures itself, we can say that there is the ration between phospholipids and vitamin E which is 3 to 1 (3:1). With this information we can calculate the whole amount of vitamin E and showed that in 220 nm radius DPPC there are about 1.5*10^7 lipids and these liposome contains about 5*10^5 vitamin E molecules.